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HSP90 inhibition overcomes EGFR amplification-induced resistance to third-generation EGFR-TKIs.

Sho WatanabeYasushi GotoHiroyuki YasudaTakashi KohnoNoriko MotoiYuichiro OheHiroyoshi NishikawaSusumu S KobayashiKazuyoshi KuwanoYosuke Togashi
Published in: Thoracic cancer (2021)
EGFR amplification confers resistance to third-generation EGFR-TKIs which can be overcome by HSP90 inhibition. The results provide a preclinical rationale for the use of HSP90 inhibitors to overcome EGFR amplification-mediated resistance.
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