HSP90 inhibition overcomes EGFR amplification-induced resistance to third-generation EGFR-TKIs.

Sho WatanabeYasushi GotoHiroyuki YasudaTakashi KohnoNoriko MotoiYuichiro OheHiroyoshi NishikawaSusumu S KobayashiKazuyoshi KuwanoYosuke Togashi

Published in: Thoracic cancer (2021)

EGFR amplification confers resistance to third-generation EGFR-TKIs which can be overcome by HSP90 inhibition. The results provide a preclinical rationale for the use of HSP90 inhibitors to overcome EGFR amplification-mediated resistance.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
heat shock protein
nucleic acid
heat shock
heat stress
stem cells
high glucose
label free