Evaluation of Cell-Specific Epigenetic Age Acceleration in People With Multiple Sclerosis.
Vicki E MaltbyAlexandre XavierEwoud EwingMaria-Pia CampagnaSandeep SampangiRodney ScottHelmut ButzkuevenVilija G JokubaitisLara KularSteffan Daniel BosMark SleeIngrid A van der MeiBruce V TaylorAnne-Louise PonsonbyMaja JagodicRodney LeaJeannette Lechner-ScottPublished in: Neurology (2023)
This study provides compelling evidence that B cells exhibit marked EAA in MS and supports the hypothesis that premature B cell immune senescence plays a role in MS. Future MS studies should focus on age-related molecular mechanisms in B cells.