Structural and functional markers of optic nerve damage in myelin oligodendrocyte glycoprotein antibody-associated optic neuritis.

Stephanie L BarnesYuyi YouTing Shen Todd A HardyClare FraserStephanie BarnesFabienne BrilotSudarshini RamanathanAlexandr KlistornerCon Yiannikas

Published in: Multiple sclerosis journal - experimental, translational and clinical (2021)

Our study demonstrated a distinct pattern of damage in MOG-ON compared to AQP4-ON and MS-ON. ON in MOGAD produces less axonal loss than AQP4-NMOSD. Damage accumulates with relapses, supporting the role of maintenance immunosuppression to induce remission. Compared to MS, MOGAD causes less demyelination.

Keyphrases

optic nerve
oxidative stress
mass spectrometry
optical coherence tomography
multiple sclerosis
ms ms
spinal cord injury
white matter
disease activity
rheumatoid arthritis
systemic lupus erythematosus