Heart-gut-microbiota communication determines the severity of cardiac injury after myocardial ischemia/reperfusion.

This study demonstrates a unique bidirectional communication along the heart-gut-microbiome-immune axis in myocardial I/R injury. Myocardial I/R injury induced gut microbiota dysbiosis and gut barrier disruption thus leading to bacterial translocation and these changes in turn aggravated I/R injury by augmenting inflammation. Furthermore, our study sheds new light on the application of GLP-2 as a promising therapy targeting gut bacteria translocation in myocardial I/R injury. These findings highlight the gut microbiota targeting therapy as a potential therapeutics strategy to attenuate myocardial I/R injury and are of great translational value.