Sacubitril/valsartan ameliorates renal tubulointerstitial injury through increasing renal plasma flow in a mouse model of type 2 diabetes with aldosterone excess.
Haruomi NishioAkira IshiiHiroyuki YamadaKeita P MoriYukiko KatoShoko OhnoTakaya HandaSayaka SugiokaTakuya IshimuraAkie IkushimaYui InoueNaoto MinaminoMasashi MukoyamaMotoko YanagitaHideki YokoiPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023)
In a mouse model of type 2 diabetes with aldosterone excess, SAC/VAL increased RPF and GFR, and ameliorated tubulointerstitial fibrosis. Furthermore, RPF negatively correlated well with tubulointerstitial injury, suggesting that the beneficial effects of SAC/VAL could be through increased renal plasma flow with enhanced natriuretic peptide bioavailability.
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