Cilastatin Ameliorates Rhabdomyolysis-induced AKI in Mice.

Katsuyuki MatsushitaKiyoshi Mori Turgay SaritasMahaba B EiwazYoshio FunahashiMegan N NickersonJessica F Hebert Adam C Munhall James A McCormick Motoko Yanagita Michael P Hutchens

Published in: Journal of the American Society of Nephrology : JASN (2021)

We conclude that megalin plays a critical role in rhabdomyolysis-induced AKI, and megalin interference and inhibition ameliorate rhabdomyolysis-induced AKI. Further investigation of megalin inhibition may inform translational investigation of a novel potential therapy.

Keyphrases

acute kidney injury
high glucose
diabetic rats
metabolic syndrome
endothelial cells
type diabetes
mouse model
risk assessment
mesenchymal stem cells
climate change
insulin resistance
human health