Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia.
Frank E H P van BaarleEmma K van de WeerdtWalter J F M van der VeldenRoelof A RuiterkampPieter R TuinmanPaula F YpmaWalter M van den BerghAstrid M P DemandtEmile D KerverArend Jan Gerard JansenPeter E WesterweelSesmu M ArbousRogier M DetermannWalther N K A van MookMirelle KoemanAnja B U MäkelburgKrijn P van LiendenJan M BinnekadeBart J BiemondAlexander P. J. VlaarPublished in: The New England journal of medicine (2023)
The withholding of prophylactic platelet transfusion before CVC placement in patients with a platelet count of 10,000 to 50,000 per cubic millimeter did not meet the predefined margin for noninferiority and resulted in more CVC-related bleeding events than prophylactic platelet transfusion. (Funded by ZonMw; PACER Dutch Trial Register number, NL5534.).