Preclinical Assessment with Clinical Validation of Selinexor with Gemcitabine and Nab-Paclitaxel for the Treatment of Pancreatic Ductal Adenocarcinoma.
Asfar S AzmiHusain Yar KhanIrfana MuqbilAmro AboukameelJasper Edgar NeggersDirk DaelemansAmit MahipalGregory DysonMandana KamgarMohammad Najeeb Al-HallakAnteneh A TesfayeSteve H KimVinod ShidhamRamzi M MohammadPhilip A PhilipPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Our preclinical and ongoing clinical study lends support to the use of selinexor-GEM-nab-paclitaxel as an effective therapy for metastatic PDAC.