Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study.

Katsuhiko OhoriToshiyuki YanoSatoshi KatanoRyohei NagaokaRyo NumazawaKotaro YamanoYusuke FujisawaHidemichi KouzuMasayuki KoyamaNobutaka NaganoTakefumi FujitoRyo NishikawaWataru OhwadaMasato Furuhashi

Published in: Drugs & aging (2023)

Use of PPIs is associated with a high risk of muscle wasting in HF patients. Caution is warranted when long-term PPI treatment is performed in sarcopenic HF patients and HF patients with several risk factors for muscle wasting.

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
ejection fraction
skeletal muscle
patient reported outcomes
peritoneal dialysis
heart failure
combination therapy