Layer-specific Nos3 expression and genotypic distribution in bicuspid aortic valve aortopathy.
Jennifer C HillMarie BillaudTara D RichardsMary P KotlarczykSruti ShivaJulie A PhillippiThomas G GleasonPublished in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2022)
These findings of differential Nos3 in media/intima versus adventitia depending on valve morphology or aneurysm reveal new information regarding aneurysmal pathophysiology and support our ongoing assertion that there are distinct mechanisms giving rise to ascending aortopathy in BAV and TAV patients.
Keyphrases
- aortic valve
- aortic stenosis
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve replacement
- ejection fraction
- end stage renal disease
- newly diagnosed
- nitric oxide synthase
- prognostic factors
- peritoneal dialysis
- single cell
- type diabetes
- heart failure
- dna methylation
- cardiovascular disease
- pulmonary hypertension
- left ventricular
- cardiovascular risk factors
- long non coding rna