Future Prospects of Positron Emission Tomography-Magnetic Resonance Imaging Hybrid Systems and Applications in Psychiatric Disorders.
Young-Don SonYoung-Bo KimJong-Hoon KimJeong Hee KimDae-Hyuk KwonHaigun LeeZang-Hee ChoPublished in: Pharmaceuticals (Basel, Switzerland) (2022)
A positron emission tomography (PET)-magnetic resonance imaging (MRI) hybrid system has been developed to improve the accuracy of molecular imaging with structural imaging. However, the mismatch in spatial resolution between the two systems hinders the use of the hybrid system. As the magnetic field of the MRI increased up to 7.0 tesla in the commercial system, the performance of the MRI system largely improved. Several technical attempts in terms of the detector and the software used with the PET were made to improve the performance. As a result, the high resolution of the PET-MRI fusion system enables quantitation of metabolism and molecular information in the small substructures of the brainstem, hippocampus, and thalamus. Many studies on psychiatric disorders, which are difficult to diagnose with medical imaging, have been accomplished using various radioligands, but only a few studies have been conducted using the PET-MRI fusion system. To increase the clinical usefulness of medical imaging in psychiatric disorders, a high-resolution PET-MRI fusion system can play a key role by providing important information on both molecular and structural aspects in the fine structures of the brain. The development of high-resolution PET-MR systems and their potential roles in clinical studies of psychiatric disorders were reviewed as prospective views in future diagnostics.
Keyphrases
- positron emission tomography
- computed tomography
- contrast enhanced
- high resolution
- magnetic resonance imaging
- pet ct
- pet imaging
- diffusion weighted imaging
- mass spectrometry
- magnetic resonance
- healthcare
- current status
- tandem mass spectrometry
- dual energy
- multiple sclerosis
- single molecule
- photodynamic therapy
- risk assessment
- high speed
- liquid chromatography
- health information
- cerebral ischemia
- simultaneous determination
- cognitive impairment
- liquid chromatography tandem mass spectrometry
- deep brain stimulation
- human health