Allogeneic CAR T Cells Targeting DLL3 Are Efficacious and Safe in Preclinical Models of Small Cell Lung Cancer.

Yi Zhang Silvia K Tacheva-Grigorova Janette Sutton Zea Melton Yvonne S L Mak Cecilia Lay Bryan A Smith Tao Sai Thomas J Van Blarcom Barbra Johnson Sasu Siler H Panowski

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

In summary, the preclinical efficacy and safety data presented here support further evaluation of DLL3 CAR T cells as potential clinical candidates for the treatment of SCLC.

Keyphrases

small cell lung cancer
induced apoptosis
stem cell transplantation
cell therapy
cell cycle arrest
bone marrow
big data
stem cells
cancer therapy
brain metastases
endoplasmic reticulum stress
mesenchymal stem cells
cell death
machine learning
deep learning