Lineage-Specific Induced Pluripotent Stem Cell-Derived Smooth Muscle Cell Modeling Predicts Integrin Alpha-V Antagonism Reduces Aortic Root Aneurysm Formation in Marfan Syndrome Mice.
Ken NakamuraAlex R DalalNobu YokoyamaAlbert J PedrozaSho KusadokoroOlivia MitchelCasey GillesBahar MasoudianMatthew LeipzigKerriann M CaseyWilliam HiesingerTetsuro UchidaMichael P FischbeinPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
mice. Integrin αv blockade via GLPG0187 may be a promising therapeutic approach to inhibit MFS aneurysmal growth.