Impact of sodium glucose linked cotransporter-2 inhibition on renal microvascular oxygen tension in a rodent model of diabetes mellitus.

Gregory M T HareYanling ZhangKyle ChinKerri ThaiEvelyn JacobsMelina P Cazorla-BakLinda NghiemDavid F WilsonSergei A VinogradovKim A ConnellyC David MazerRoger G EvansRichard E Gilbert

Published in: Physiological reports (2022)

These findings indicate that microvascular kidney oxygen tension is maintained in the superficial cortex but reduced in deeper cortical and outer medullary tissue, possibly due to the regional impact of SGLT-2 inhibition on tissue metabolism. This reduction in deeper Pk O2 had biological impact as demonstrated by increased renal EPO mRNA levels and circulating reticulocyte count.

Keyphrases

functional connectivity
peripheral blood
binding protein
skeletal muscle
adipose tissue
glycemic control
weight loss