Relationship of circulating insulin-like growth factor-I and binding proteins 1-7 with mammographic density among women undergoing image-guided diagnostic breast biopsy.
Manila HadaHannah OhRuth M PfeifferRoni T FalkShaoqi FanMaeve MulloolyMichael PollakBerta GellerPamela M VacekDonald WeaverJohn ShepherdJeff WangBo FanAmir Pasha MahmoudzadehSerghei MalkovSally HerschornLouise A BrintonMark E ShermanGretchen L GierachPublished in: Breast cancer research : BCR (2019)
In this comprehensive study of IGFBPs and MD, we observed a novel positive association between IGFBP-2 and MD, particularly among women with lower BMI. In concert with in vitro studies suggesting a dual role of IGFBP-2 on breast tissue, promoting cell proliferation as well as inhibiting tumorigenesis, our findings suggest that further studies assessing the role of IGFBP-2 in breast tissue composition, in addition to IGF-1 and IGFBP-3, are warranted.