Evaluation and Application of a PET Tracer in Preclinical and Phase 1 Studies to Determine the Brain Biodistribution of Minzasolmin (UCB0599).
Joël MercierMassimo BaniAnny-Odile ColsonMassimiliano GermaniMarianna LallaChristophe PlissonMickael HuibanGraham SearleFrançois-Xavier MathyRichard NichollChristian OtoulJohan Willem SmitVanja van AschMichel WagneurRalph Paul MaguirePublished in: Molecular imaging and biology (2023)
C]minzasolmin was used in the phase 1 study, which demonstrated that minzasolmin readily crossed the blood-brain barrier and was well distributed throughout the brain. Safety and pharmacokinetic findings were consistent with previous early-phase studies (such as UP0077, NCT04875962).