Efficacy of Rituximab and Plasma Exchange in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis with Severe Kidney Disease.
Marta Casal MouraMaria V IrazabalAlfonso EirinLadan ZandSanjeev SethiBijan J BorahJeffrey L WintersJames P MoriartyRodrigo Cartin-CebaAlvise BertiMisbah BaqirGwen E ThompsonAshima MakolKenneth J WarringtonViengneesee ThaoUlrich SpecksFernando C FervenzaPublished in: Journal of the American Society of Nephrology : JASN (2020)
The apparent benefits and risks of using CYC or RTX for the treatment of patients with AAV and severe kidney disease are balanced. The addition of PLEX to standard remission-induction therapy showed no benefit in our cohort. A randomized controlled trial is the only satisfactory means to evaluate efficacy of remission-induction treatments in AAV with severe renal involvement.