Counteracting roles of MHCI and CD8+ T cells in the peripheral and central nervous system of ALS SOD1G93A mice.
Giovanni NardoMaria Chiara TroleseMattia VerderioAlessandro MarianiMassimiliano de PaolaNilo RivaGiorgia DinaNicolò PaniniEugenio ErbaAngelo QuattriniCaterina BendottiPublished in: Molecular neurodegeneration (2018)
We provided straightforward evidence for a dual role of MHCI in the peripheral nervous system (PNS) compared to the CNS, pointing out regional and temporal differences in the clinical responses of ALS mice. These findings offer a possible explanation for the failure of systemic immunomodulatory treatments and suggest new potential strategies to prevent the progression of ALS.