Identification of Key Genes and Signaling Pathways in Entrectinibresistant Non-small Cell Lung Cancer Using Bioinformatic Analysis and Experimental Verification.

Xuesong ChenXin ZhaoDongbing Li Wangjian Zha

Published in: Current medicinal chemistry (2024)

We have identified core genes associated with non-small cell resistance to entrectinib, including CHI3L2, ZEB2, and S100A12. ZEB2 is a core gene associated with acquired resistance to entetinib in NSCLC.

Keyphrases

epithelial mesenchymal transition
genome wide
long non coding rna
signaling pathway
bioinformatics analysis
small cell lung cancer
genome wide identification
single cell
cell therapy
copy number
advanced non small cell lung cancer
stem cells
dna methylation
pi k akt
transcription factor
gene expression