Unveiling the therapeutic potential of Dl-3-n-butylphthalide in NTG-induced migraine mouse: activating the Nrf2 pathway to alleviate oxidative stress and neuroinflammation.
Yingyuan LiuZihua GongDeqi ZhaiChunxiao YangGuangshuang LuShuqing WangShaobo XiaoChenhao LiLudan ChenXiaoxue LinShuhua ZhangSheng-Yuan YuZhao DongPublished in: The journal of headache and pain (2024)
Our data suggest that NBP may alleviate migraine by activating the Nrf2 pathway to reduce oxidative stress and inflammation in migraine mouse models, confirming that it may be a potential drug for the treatment of migraine.
Keyphrases
- oxidative stress
- diabetic rats
- dna damage
- ischemia reperfusion injury
- induced apoptosis
- mouse model
- high glucose
- big data
- machine learning
- climate change
- artificial intelligence
- lipopolysaccharide induced
- blood brain barrier
- cognitive impairment
- combination therapy
- endothelial cells
- deep learning
- heat stress
- stress induced
- data analysis