Macitentan attenuates cardiovascular remodelling in infant rats with chronic lung disease.

Philipp BaumannFrancesco GrecoSusanne WiegertSven WellmannGiovanni PellegriniVincenzo Cannizzaro

Published in: Journal of translational medicine (2022)

The endothelin-1 receptor antagonist macitentan attenuated cardiovascular remodelling in an infant rat model for preterm chronic lung disease. This study underscores the potential of macitentan to reduce cardiovascular morbidity in preterm infants with chronic lung disease.

Keyphrases

preterm infants
pulmonary arterial hypertension
low birth weight
risk assessment
human health