An adiponectin-S1P autocrine axis protects skeletal muscle cells from palmitate-induced cell death.

Amy BottaKazaros ElizbaryanParastoo TashakoriniaNhat Hung LamGary Sweeney

Published in: Lipids in health and disease (2020)

This data indicates that increased extracellular levels of S1P in response to adiponectin receptor activation can activate S1P receptor-mediated signaling to attenuate lipotoxic cell death. Taken together these findings represent a possible novel mechanism for the protective action of adiponectin.

Keyphrases

cell death
insulin resistance
skeletal muscle
metabolic syndrome
cell cycle arrest
high glucose
adipose tissue
diabetic rats
type diabetes
electronic health record
big data
drug induced
machine learning
binding protein
artificial intelligence
data analysis