Compromised browning in white adipose tissue of aging people.

Ping GuKai DingLei LuYu ZhangWei WangQingyu GuoYannian LiaoBingjie YangTiantian WangChangsheng ZhouBin LuAlice P S KongAlfred S ChengHannah Xiaoyan HuiJiaqing Shao

Published in: European journal of endocrinology (2023)

PRDM16 and UCP1, despite their key functions in adipose browning, exhibit differential clinical correlations with metabolic features in human WAT in an age-dependent manner. These two genes may participate in the pathogenesis of aging-related metabolic diseases, but with distinct mechanisms.

Keyphrases

adipose tissue
insulin resistance
endothelial cells
high fat diet induced
high fat diet
genome wide
induced pluripotent stem cells
type diabetes
gene expression
metabolic syndrome
skeletal muscle
transcription factor