Insulin sensitivity predicts cognitive decline in individuals with prediabetes.

Caroline WillmannKathrin BrockmannRobert WagnerStephanie KullmannHubert PreisslGünter SchnauderWalter MaetzlerThomas GasserDaniela BergGerhard W EschweilerFlorian MetzgerAndreas J FallgatterHans-Ulrich HäringAndreas FritscheMartin Heni

Published in: BMJ open diabetes research & care (2021)

Insulin resistance rather than sole elevation of blood glucose predicts cognitive decline, specifically in the memory domain, in persons with prediabetes. Treatments of diabetes that improve insulin sensitivity might therefore have the potential to postpone or even prevent cognitive decline in patients with diabetes.

Keyphrases

cognitive decline
blood glucose
glycemic control
mild cognitive impairment
insulin resistance
type diabetes
cardiovascular disease
metabolic syndrome
adipose tissue
blood pressure
risk assessment
high fat diet induced