Boswellia serrata Extract, 5-Loxin®, Prevents Joint Pain and Cartilage Degeneration in a Rat Model of Osteoarthritis through Inhibition of Inflammatory Responses and Restoration of Matrix Homeostasis.
Mi-Rae ShinHwa-Young KimHwang-Yong ChoiKyoung Sik ParkHak Joo ChoiSeong-Soo RohPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
Osteoarthritis (OA) is a chronic, progressive joint disease associated with pain, functional impairment, and diminished quality of life in affected individuals. At a societal level, it also has a high economic burden. Boswellia serrata has been reported to have potent anti-inflammatory, antiarthritic, and analgesic effects. The aim of this study was to explore the therapeutic potential and possible underlying mechanism of 5-Loxin®, a standardized Boswellia serrata extract, in a rat model of OA. The OA model was established by the intra-articular injection of 50 μ L of monosodium iodoacetate (MIA) (60 mg/mL). 5-Loxin® was administered orally, and efficacy was evaluated through serum analysis, real-time polymerase chain reaction (PCR), histologic staining, and micro-computed tomography (micro-CT). Results indicated that administration of 5-Loxin® can relieve OA joint pain through inhibition of both inflammatory processes and cartilage degeneration. In the group of rats treated with 5-Loxin®, the suppression of inflammatory enzymes such as cyclooxygenase (COX)-2 and 5-lipoxygenase (LOX) resulted in a significant reduction in the prostaglandin (PG) E 2 and leukotriene (LT) B 4 levels. Moreover, 5-Loxin® ameliorated the deterioration of the main components of the articular extracellular matrix (ECM), such as glycosaminoglycans (GAGs) and aggrecan, through the downregulation of matrix metalloproteinases (MMPs). These findings suggest that 5-Loxin® may be a potential therapeutic agent for the treatment of OA.
Keyphrases
- extracellular matrix
- knee osteoarthritis
- anti inflammatory
- chronic pain
- computed tomography
- neuropathic pain
- pain management
- oxidative stress
- rheumatoid arthritis
- positron emission tomography
- multiple sclerosis
- spinal cord
- magnetic resonance imaging
- spinal cord injury
- signaling pathway
- contrast enhanced
- cell proliferation
- image quality
- flow cytometry
- newly diagnosed
- magnetic resonance