Collagen methionine sulfoxide and glucuronidine/LW-1 are markers of coronary artery disease in long-term survivors with type 1 diabetes. The Dialong study.
Kristine B HolteMona SvantesonKristian F HanssenKari Anne SveenIngebjørg SeljeflotSvein SolheimDavid R SellVincent M MonnierTore Julsrud BergPublished in: PloS one (2020)
Low levels of collagen-bound methionine sulfoxide were associated with normal coronary arteries while glucuronidine/LW-1 was positively associated with established CHD in long-term type 1 diabetes, suggesting a role for metabolic and oxidative stress in the formation of atherosclerosis in diabetes.
Keyphrases
- coronary artery disease
- type diabetes
- cardiovascular disease
- oxidative stress
- glycemic control
- cardiovascular events
- percutaneous coronary intervention
- coronary artery bypass grafting
- wound healing
- dna damage
- tissue engineering
- insulin resistance
- aortic stenosis
- adipose tissue
- induced apoptosis
- skeletal muscle
- aortic valve
- ejection fraction
- transcatheter aortic valve replacement