Causal Relationship Between Sleep Traits and Hypothalamic-Pituitary-Target Gland Axis Function: A Mendelian Randomization Study.

Zi-Yu RenJiangchuan LongWenzhen DengYuanyuan JingJingwen QiuWei Ren Dongfang Liu

Published in: Nature and science of sleep (2024)

Our MR analysis indicated a significant causal association between chronotype and suppressed gonadal function in healthy adult humans, with no apparent gender-specific effect. Extreme sleep durations were also found to be detrimental to the maintenance of normal HPTGA secretion function. Compared to males, gonadal function in the female cohort is more susceptible to extreme sleep habits. Subsequent observational studies are urgently needed to confirm the underlying mechanisms.

Keyphrases

physical activity
sleep quality
climate change
mental health
magnetic resonance
computed tomography
depressive symptoms
data analysis