Fetal Lung Interstitial Tumor: A Comprehensive Case Study with an Emphasis on Next-Generation Sequencing.
Yoo Jin JungSeongyeon JungJiwon KohJaemoon KohYoon Kyung JeonHye-Kyung ParkEun Na KimChang Hyun KangPublished in: Journal of chest surgery (2024)
Fetal lung interstitial tumor (FLIT), which is characterized by immature interstitial cells resembling the fetal lung parenchyma of 20 to 24 weeks of gestation, is a rare respiratory neoplasm. This study presents the first reported FLIT in Korea. It also aims to refine the diagnostic method of FLIT and increase the accuracy of prognostic assessment by using next-generation sequencing to check for anaplastic lymphoma receptor tyrosine kinase (anaplastic lymphoma kinase) gene rearrangement. Although the initial prognosis for FLIT has been promising since its first report in 2010, certain pathological features are associated with poorer outcomes. Therefore, achieving an accurate diagnosis of FLIT is crucial for avoiding unnecessary treatments beyond surgical resection.
Keyphrases
- tyrosine kinase
- copy number
- epidermal growth factor receptor
- diffuse large b cell lymphoma
- induced apoptosis
- preterm infants
- gestational age
- cell cycle arrest
- circulating tumor
- genome wide
- gene expression
- metabolic syndrome
- low grade
- oxidative stress
- cell death
- cell proliferation
- binding protein
- signaling pathway
- mass spectrometry
- cell free