Soluble Epoxide Hydrolase Inhibitor TPPU Alleviates Nab-Paclitaxel-Induced Peripheral Neuropathic Pain via Suppressing NF- κ B Signalling in the Spinal Cord of a Rat.
Xing WeiLijun JiaYaqing ZhouWeimiao LiChangyou ShanShuqun ZhangYonglin ZhaoPublished in: Pain research & management (2023)
These findings support a role for sEH in PIPN and suggest that the inhibition of sEH represents a potential new therapeutic target for PIPN.
Keyphrases
- neuropathic pain
- spinal cord
- signaling pathway
- spinal cord injury
- oxidative stress
- diabetic rats
- high glucose
- chemotherapy induced
- lps induced
- pi k akt
- drug induced
- advanced non small cell lung cancer
- endothelial cells
- immune response
- inflammatory response
- cell proliferation
- toll like receptor
- epidermal growth factor receptor