5-Aryl-1-Arylideneamino-1H-Imidazole-2(3H)-Thiones: Synthesis and In Vitro Anticancer Evaluation.
Ali Hussein Abu AlmaatyEslam E M TosonEl-Sherbiny H El-SayedMohamed A M TantawyEman FayadOla A Abu AliIslam ZakiPublished in: Molecules (Basel, Switzerland) (2021)
A novel series of N-1 arylidene amino imidazole-2-thiones were synthesized, identified using IR, 1H-NMR, and 13C-NMR spectral data. Cytotoxic effect of the prepared compounds was carried out utilizing three cancer cell lines; MCF-7 breast cancer, HepG2 liver cancer, and HCT-116 colon cancer cell lines. Imidazole derivative 5 was the most potent of all against three cell lines. DNA flow cytometric analysis showed that, imidazoles 4d and 5 exhibit pre-G1 apoptosis and cell cycle arrest at G2/M phase. The results of the VEGFR-2 and B-Raf kinase inhibition assay revealed that compounds 4d and 5 displayed good inhibitory activity compared with reference drug erlotinib.
Keyphrases
- cell cycle arrest
- cell death
- pi k akt
- magnetic resonance
- high resolution
- solid state
- circulating tumor
- signaling pathway
- high throughput
- cell proliferation
- optical coherence tomography
- breast cancer cells
- oxidative stress
- vascular endothelial growth factor
- endoplasmic reticulum stress
- big data
- magnetic resonance imaging
- data analysis
- cell free
- protein kinase
- emergency department
- epidermal growth factor receptor
- computed tomography
- nucleic acid
- anti inflammatory
- drug induced
- water soluble
- clinical evaluation