Progressive Multifocal Leukoencephalopathy Treated by Immune Checkpoint Inhibitors.
Xavier BoumazaBaptiste BonneauDamien Roos-WeilCarmela PinnettiSebastian RauerLouisa NitschArnaud Del BelloIlijas JelcicKurt-Wolfram SühsJacques GasnaultYasemin GoreciOliver GrauerSharmilee GnanapavanRebecca WickleinNicolas LambertThomas PerpointMartijn BeudelDavid CliffordAgnès SommetIrene CorteseGuillaume Martin-Blondelnull nullPublished in: Annals of neurology (2022)
In this noncontrolled retrospective study of patients with PML who were treated with immune checkpoint inhibitors, mortality remains high. Development of inflammatory features or overt PML-IRIS was commonly observed. This study highlights that use of immune checkpoint inhibitors should be strictly personalized toward characteristics of the individual PML patient. ANN NEUROL 2022.