Caveolar Compartmentalization is Required for Stable Rhythmicity of Sinus Nodal Cells and is Disrupted in Heart Failure.
Di LangHaibo NiRoman Y MedvedevFang LiuClaudia P Alvarez-BaronLeonid TyanDaniel G P TurnerAleah WardenStefano MorottiThomas A SchrauthChristian RickertCatherine ProenzaBaron ChandaTimothy J KampGail A RobertsonEleonora GrandiAlexey V GlukhovPublished in: bioRxiv : the preprint server for biology (2024)
SAN pacemaking is driven by complex protein interactions within a nanoscale caveolar pacemaker signalosome. Disruption of caveolae leads to SND, potentially representing a new dimension of SAN remodeling and providing a newly recognized target for therapy.
Keyphrases
- heart failure
- induced apoptosis
- cell cycle arrest
- lymph node
- endoplasmic reticulum stress
- atrial fibrillation
- left ventricular
- signaling pathway
- resting state
- binding protein
- protein protein
- squamous cell carcinoma
- cell death
- oxidative stress
- pulmonary embolism
- small molecule
- high resolution
- cardiac resynchronization therapy
- bone marrow
- mass spectrometry
- functional connectivity
- cell proliferation
- radiation therapy
- smoking cessation
- single molecule