A new WHO bottle bioassay method to assess the susceptibility of mosquito vectors to public health insecticides: results from a WHO-coordinated multi-centre study.
Vincent CorbelMara D KontMartha Liliana AhumadaLaura AndréoBazoma BayiliKoama BayiliBasil BrookeJesús A Pinto CaballeroBen LambertThomas S ChurcherStephane DuchonJosiane EtangAdriana E FloresKasinathan GunasekaranWaraporn JuntarajumnongMatt KirbyRachel DaviesRosemary Susan LeesAudrey LenhartJosé Bento Pereira LimaAdemir J MartinsPie MüllerRaphael N'GuessanCorine NguforGiorgio PraulinsMartha QuinonesKamaraju RaghavendraVaishali VermaAdanan Che RusMichael SamuelKoou Sin YingSungsit SungvornyothinSreehari UragayalaRaman VelayudhanRajpal S YadavPublished in: Parasites & vectors (2023)
Our findings, based on the largest susceptibility dataset ever produced on mosquitoes, showed that the new WHO bottle bioassay is adequate for evaluating mosquito susceptibility to new and promising public health insecticides currently deployed for vector control. The datasets presented in this study have been used recently by the WHO to establish 17 new insecticide discriminating concentrations (DCs) for either Aedes spp. or Anopheles spp. The bottle bioassay and DCs can now be widely used to monitor baseline insecticide susceptibility of wild populations of vectors of malaria and Aedes-borne diseases worldwide.