Dolabrane-Type Diterpenoids with Immunosuppressive Activity from Koilodepas hainanense .
Yu RenXiao TongYe ZhaoShi-Jun HeYao-Yue FanJian-Min YuePublished in: Journal of natural products (2022)
Thirteen new dolabrane-type diterpenoids, koilodenoids A-M ( 1 - 13 ), including a chlorinated congener ( 2 ), along with six known analogues, were isolated from Koilodepas hainanense . The structures were determined by analysis of spectroscopic data, ECD spectra, and X-ray crystallographic studies. The absolute configuration of C-15 in the 15,16-diol unit of compounds 4 and 5 was established by using the dimolybdenum tetraacetate [Mo 2 (AcO) 4 ]-induced ECD method. Compounds 4 , 7 , 16 , 17 , and 19 showed moderate to significant immunosuppressive activities against the proliferation of T and B lymphocytes in vitro , with compound 16 being the most potent (IC 50 0.86 and 0.29 μM, respectively).
Keyphrases
- molecular docking
- high resolution
- high glucose
- signaling pathway
- diabetic rats
- peripheral blood
- high intensity
- electronic health record
- big data
- magnetic resonance imaging
- mass spectrometry
- oxidative stress
- case control
- drug induced
- endothelial cells
- computed tomography
- molecular dynamics simulations
- data analysis
- contrast enhanced