Neuroprotective effect of microglia against impairments of auditory steady-state response induced by anti-P IgG from SLE patients in naïve mice.
Xuejiao WangYingzhuo LiZijie LiJinhong LiJingyi XuPingting YangLing QinPublished in: Journal of neuroinflammation (2020)
Our study indicates that anti-P antibodies can directly induce the dysfunction of auditory-evoked potentials in the brain and that microglia are involved in the protection of neural activity after the invasion of anti-P antibodies, which could have important implications for NPSLE.
Keyphrases
- end stage renal disease
- inflammatory response
- working memory
- systemic lupus erythematosus
- newly diagnosed
- chronic kidney disease
- ejection fraction
- neuropathic pain
- oxidative stress
- prognostic factors
- cerebral ischemia
- white matter
- patient reported outcomes
- cell migration
- rheumatoid arthritis
- metabolic syndrome
- spinal cord injury
- brain injury