Obesity-induced cognitive impairment in older adults: a microvascular perspective.
Priya BalasubramanianTamas KissStefano TarantiniÁdám Nyúl-TóthChetan AhireAndriy YabluchanskiyTamas CsipoAgnes LipeczAdam TabakAdam InstitorisAnna CsiszarZoltan UngvariPublished in: American journal of physiology. Heart and circulatory physiology (2020)
Over two-thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between the degree of adiposity and cognitive dysfunction in the elderly. In this review, the pathophysiological roles of microvascular mechanisms, including impaired endothelial function and neurovascular coupling responses, microvascular rarefaction, and blood-brain barrier disruption in the genesis of cognitive impairment in geriatric obesity are considered. The potential contribution of adipose-derived factors and fundamental cellular and molecular mechanisms of senescence to exacerbated obesity-induced cerebromicrovascular impairment and cognitive decline in aging are discussed.
Keyphrases
- weight loss
- cognitive impairment
- blood brain barrier
- insulin resistance
- cognitive decline
- weight gain
- metabolic syndrome
- type diabetes
- high fat diet induced
- high glucose
- bariatric surgery
- physical activity
- diabetic rats
- adipose tissue
- mild cognitive impairment
- endothelial cells
- middle aged
- body mass index
- cerebral ischemia
- drug induced
- oxidative stress
- obese patients
- dna damage
- machine learning
- stress induced
- human health
- electron transfer