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Losing the chain of thought: A meta-analysis of functional neuroimaging studies using verbal tasks in schizophrenia.

Florence PilonMélanie BoisvertStéphane Potvin
Published in: Journal of psychiatric research (2023)
In schizophrenia, hyperactivations were observed in the left inferior frontal gyrus (IFG) and middle frontal gyrus (MFG) and hypoactivations were observed in the right IFG, the precentral gyrus and the left caudate nucleus. Another analysis pooling hyper- and hypoactivations revealed altered activations, firstly, in the left IFG and MFG, secondly, in the left precentral gyrus, IFG and insula, and, thirdly, in the left angular gyrus and precuneus. In the light of these results, not only classic language-related regions are abnormally activated during verbal tasks in schizophrenia, but also brain regions involved in executive functions, autobiographical memory and, unexpectedly, in motor functions. Further functional neuroimaging studies are needed to investigate the role of the striatum in linguistic sequencing in schizophrenia.
Keyphrases
  • working memory
  • bipolar disorder
  • functional connectivity
  • resting state
  • autism spectrum disorder
  • white matter
  • prefrontal cortex