Smart Polymeric Nanoparticles with pH-Responsive and PEG-Detachable Properties (II): Co-Delivery of Paclitaxel and VEGF siRNA for Synergistic Breast Cancer Therapy in Mice.

Mingji JinYan HouXiuquan QuanLiqing ChenZhong-Gao GaoWei Huang

Published in: International journal of nanomedicine (2021)

The combination of PTX and VEGF siRNA exerts good antitumor effect on 4T1 tumor cells. This study provides a theoretical and practical basis for breast cancer therapy.

Keyphrases

cancer therapy
drug delivery
vascular endothelial growth factor
endothelial cells
drug release
type diabetes
high fat diet induced
insulin resistance
wild type