ApoA-I Protects Pancreatic β-Cells From Cholesterol-Induced Mitochondrial Damage and Restores Their Ability to Secrete Insulin.

Bikash ManandharElvis PandzicNandan DeshpandeSing-Young ChenValerie C Wasinger Maaike KockxElias GlarosKwok-Leung OngShane R ThomasMarc R WilkinsRenee M WhanBlake J Cochran Kerry-Anne Rye

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

These results establish that β-cells are functionally heterogeneous, and apoA-I restores insulin secretion in β-cells with elevated cholesterol levels by improving mitochondrial redox balance.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
type diabetes
diabetic rats
low density lipoprotein
endoplasmic reticulum stress
cell death
signaling pathway
high glucose
drug induced
electron transfer