Arrhythmogenic Right Ventricular Cardiomyopathy Prevalence and Arrhythmic Outcomes in At-Risk Family Members: A Systematic Review and Meta-Analysis.

Apurva Sharma Laurens P BosmanCrystal TichnellJulie NanavatiBrittney Murray Bareng A S Nonyane Harikrishna Tandri Hugh Calkins Cynthia A James

Published in: Circulation. Genomic and precision medicine (2022)

The prevalence of ARVC and VA in at-risk family members differs significantly based on family genotype. Although recent recommendations provide a guideline based only on age, we propose screening every 1 to 2 years for gene-positive family members and every 3 to 5 years for first-degree relatives of gene-elusive cases, as long as they are asymptomatic and not athletes.

Keyphrases

risk factors
copy number
genome wide
genome wide identification
type diabetes
gene expression
adipose tissue
metabolic syndrome