Disposition and Metabolomic Effects of 2,2',5,5'-Tetrachlorobiphenyl in Female Rats Following Intraperitoneal Exposure.
Amanda BullertXueshu LiChunyun ZhangKendra LeeCasey F PulliamBrianna S CagleJonathan A DoornAloysius J KlingelhutzLarry W RobertsonHans-Joachim LehmlerPublished in: bioRxiv : the preprint server for biology (2023)
PCB 52 was present in adipose, brain, liver, and serum 3 weeks after PCB exposureLiver and serum contained hydroxylated, sulfated, and methylated PCB 52 metabolitesMetabolomics analysis revealed minor changes in endogenous serum metabolitesLevels of dopamine and its metabolites in the brain were not affected by PCB 52.