MPAI-Ligand Accelerated Pd-Catalyzed C(<i>sp</i>³)-H Arylation of Free Aliphatic Acids.

Here, we report the development of a class of bifunctional monoprotected amino-imidazoline (MPAI) ligands and their applications in Pd-catalyzed C(<i>sp</i>³)-H arylation of free aliphatic acids. The newly developed MPAI ligand allows the use of 1.0 equiv of aliphatic acids containing an alpha hydrogen for the first time.