Deletion of the endothelial glycocalyx component endomucin leads to impaired glomerular structure and function.
Zhengping HuIssahy CanoFengyang LeiJie LiuRamon Bossardi RamosHarper GordonEleftherios I PaschalisMagali Saint-GeniezYin Shan Eric NgPatricia A D'AmorePublished in: bioRxiv : the preprint server for biology (2024)
Our study demonstrates a critical role of the endothelial marker EMCN in supporting normal glomerular filtration barrier structure and function by maintaining glomerular endothelial tight junction and homeostasis and podocyte function through endothelial-podocyte crosstalk.