Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer.

Raphaël Leman Etienne Muller Angelina Legros Nicolas Goardon Imène Chentli Alexandre Atkinson Aurore Tranchant Laurent Castera Sophie Krieger Agathe Ricou Flavie Boulouard Florence Joly Lobbedez Romain Boucly Aurélie Dumont Noémie Basset Florence Coulet Louise-Marie Chevalier Etienne Rouleau Katharina Leitner Antonio Gonzáles Martin Piera Gargiulo Hans-Joachim Lück Catherine Genestienull nullIsabelle L Ray-Coquard Eric Pujade-Lauraine Dominique Vaur

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

GIScar is a valuable diagnostic tool, reliably detecting HRD and predicting sensitivity to olaparib for ovarian cancer. GIScar showed high analytic concordance with MGMC test and fewer inconclusive results. GIScar is easily implemented into diagnostic laboratories with a rapid turnaround.

Keyphrases