miR-541 potentiates the response of human hepatocellular carcinoma to sorafenib treatment by inhibiting autophagy.

Wen-Ping XuJin-Pei LiuJi-Feng FengChang-Peng ZhuYuan YangWei-Ping ZhouJin DingChen-Kai HuangYa-Lu CuiChen-Hong DingXin ZhangBin LuWei Fen Xie

Published in: Gut (2019)

Dysregulation of miR-541-ATG2A/RAB1B axis plays a critical role in patients' responses to sorafenib treatment. Manipulation of this axis might benefit survival of patients with HCC, especially in the context of the highly pursued strategies to eliminate drug resistance.

Keyphrases

cell proliferation
long non coding rna
endothelial cells
end stage renal disease
ejection fraction
cell death
endoplasmic reticulum stress