LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface.

Ø SalvesenM R ReitenA EspenesM K BakkebøM A TranulisØyvind Salvesen

Published in: Journal of neuroinflammation (2017)

Our data suggest that PrPC acts as a modulator of certain pathways of innate immunity signaling, particularly downstream of interferons, and probably contributes to protection of vulnerable tissues against inflammatory damage.

Keyphrases

lps induced
inflammatory response
oxidative stress
gene expression
resting state
electronic health record
white matter
big data
protein protein
binding protein
functional connectivity
amino acid
deep learning
brain injury
subarachnoid hemorrhage