An Ag 2 S@ZIF-Van nanosystem for NIR-II imaging of bacterial-induced inflammation and treatment of wound bacterial infection.
Yao HuangHongchao GengZeming WuLeilei SunChenhui JiCraig A GrimesXinxin FengQingyun CaiPublished in: Biomaterials science (2022)
Bacterial diseases pose a serious threat to human health. Continued development of precise diagnostic methods and synergistic therapy techniques for combating bacteria are needed. Herein a hybrid nanosystem (Ag 2 S@ZIF-Van NS) was constructed by one-step self-assembly of Zn 2+ , vancomycin (Van) and Ag 2 S quantum dots (QDs). The nanosystem possesses excellent second near-infrared transparency window (NIR-II) fluorescence properties (∼1200 nm emission wavelength), good photothermal conversion properties, and biocompatibility. The material system enables precise, targeted NIR-II fluorescent imaging of bacterial inflammation in vivo as well as promoting anti-bacterial and wound healing effects.
Keyphrases
- quantum dots
- photodynamic therapy
- human health
- oxidative stress
- high resolution
- risk assessment
- fluorescence imaging
- fluorescent probe
- sensitive detection
- energy transfer
- heavy metals
- living cells
- diabetic rats
- drug delivery
- wastewater treatment
- mesenchymal stem cells
- stem cells
- mass spectrometry
- endothelial cells
- combination therapy
- stress induced
- metal organic framework