Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors.
Julia RamírezStefan Van DuijvenbodenWilliam J YoungAndrew TinkerPier D LambiaseMichele OriniPatricia B MunroePublished in: Circulation. Genomic and precision medicine (2022)
In individuals without known cardiovascular disease, the inclusion of CV GRSs to a clinical tool and an established CAD GRS does not improve CAD or MACE risk stratification. However, their combination only with the CAD GRS increases prediction performance indicating potential use in early-life screening before the advanced development of conventional cardiovascular risk factors.
Keyphrases
- cardiovascular risk factors
- coronary artery disease
- cardiovascular events
- cardiovascular disease
- early life
- metabolic syndrome
- percutaneous coronary intervention
- coronary artery bypass grafting
- type diabetes
- emergency department
- heart failure
- dna methylation
- genome wide
- aortic stenosis
- gene expression
- risk assessment
- human health
- left ventricular