Validation of the hotspot for dorsolateral subthalamic nucleus targeting in deep brain stimulation surgery for Parkinson's disease: a post hoc analysis of a randomised controlled trial.
Erik BolierRozemarije A HolewijnRob M A De BieMartijn BeudelPepijn van den MunckhofRichard SchuurmanMaarten BotPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
We validated the hotspot for dorsolateral STN targeting in DBS for patients with PD and showed an improved motor response in poor responders, a reduced variability in motor improvement and a greater dopaminergic medication reduction. We then refined the hotspot at 2.8 mm lateral, 1.1 mm anterior and 2.2 mm superior relative to the medial STN border, which visualises a readily implementable target within the dorsolateral STN on lower field strength MRI.
Keyphrases
- deep brain stimulation
- prefrontal cortex
- parkinson disease
- working memory
- transcranial magnetic stimulation
- transcranial direct current stimulation
- obsessive compulsive disorder
- minimally invasive
- cancer therapy
- high frequency
- magnetic resonance imaging
- contrast enhanced
- coronary artery bypass
- healthcare
- magnetic resonance
- computed tomography
- drug delivery
- acute coronary syndrome
- diffusion weighted imaging
- electronic health record