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Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke.

Thomas JaworekHuichun XuBrady J GaynorJohn W ColeKristiina RannikmaeTara M StanneLiisa TomppoVida AbediPhillippe AmouyelNicole D ArmstrongJohn Richard AttiaSteven BellOscar R BenaventeGiorgio B BoncoraglioAdam S Butterworthnull nullJara Cárcel-MárquezZhengming ChenMichael ChongCruchaga CarlosAndrea N EdgintonJohn DaneshStephanie DebetteDavid J DugganJon Peter DurdaGunnar EngstromChris EnzingerJessica D FaulNatalie S FecteauIsrael Fernandez-CadenasChristian GiegerAnne-Katrin GieseRaji P GrewalUlrike GrittnerAki Samuli HavulinnaLaura HeitschMarc C HochbergElizabeth HollidayJie HuAndreea Ilincanull nullMarguerite R IrvinRebecca D JacksonMina A JacobRaquel Rabionet JanssenJordi Jiménez-CondeJulie A JohnsonYoichiro KamataniSharon L KardiaMasaru KoidoMichiaki KuboLeslie LangeJin-Moo LeeRobin LemmensChristopher R LeviJiang LiLiming LiKuang LinHaley LopezSothear LukeJane MaguirePatrick F McArdleCaitrin W McDonoughJames F MeschiaTiina MetsoMartina Müller-NuraysidTimothy D O'ConnorMartin O'DonnellLeema R PeddareddygariJoanna PeraJames A PerryAnnette PetersJukka PutaalaDebashree RayKathyrn M RexrodeMarta RibasesJonathan RosandPeter M RothwellTatjana RundekKathleen A RyanRalph L SaccoVeikko V SalomaaCristina Sánchez-MoraReinhold SchmidtPankaj SharmaAgnieszka SlowikJennifer A SmithNicholas L SmithSylvia Wassertheil-SmollerMartin SoederholmO C StineStrbian DanielCathie L M SudlowTurgut TatlisumakChikashi C TeraoVincent N ThijsNuria P Torres-AguilaDavid-Alexandre TregouetAnil Man TuladharJan Herman VeldinkRobin G WaltersDavid R WeirDaniel WooBradford B WorrallCharles C HongOwen RossRamin ZandFrank-Erik de LeeuwArne G LindgrenGuillaume ParéChristopher D AndersonHugh Stephen MarkusChristina JernRainer MalikMartin DichgansBraxton D MitchellSteven J Kittnernull null
Published in: Neurology (2022)
locus, genetically predicted blood group A, and higher genetic propensity for venous thrombosis are more strongly associated with EOS than with LOS, supporting a stronger role of prothrombotic factors in EOS.
Keyphrases
  • early onset
  • late onset
  • atrial fibrillation
  • genome wide
  • copy number
  • genome wide association study
  • gene expression
  • dna methylation